I aim to show that the practice of reading excellent literature is an excellent form of moral education. I offer a two-stage defense. First, I call attention to central features of the human self (especially the emotions) involved in moral growth. I argue that the central components of emotions are construals (or ways of seeing) and loves. Second, I show that literature has distinctive resources both to train our construals by affording us practice in seeing the world in new ways (...) and to cultivate our loves by affording us practice in imitating the loves of others. (shrink)

We know from experience that a stable feature of the human predicament is internal alienation: our various psychic states are often in conflict with one another. We are divided selves. In this paper, I delineate the nature and argue for the importance of a spiritual discipline of reading literature as a way of addressing this division. My argument comes in two stages. First, I offer a diagnosis of why we fail to be wholehearted that develops Aristotle’s idea that a fundamental (...) source of internal division within the soul is between what we know and how we see or construe our present situation. Second, I show how a spiritual discipline of reading literature is the right prescription for retraining our habits of construal so as to bring them into harmony with our knowledge. I conclude with a few remarks about how to put this discipline into practice. (shrink)

In this book, Christopher Evan Franklin develops and defends a novel version of event-causal libertarianism. This view is a combination of libertarianism--the view that humans sometimes act freely and that those actions are the causal upshots of nondeterministic processes--and agency reductionism--the view that the causal role of the agent in exercises of free will is exhausted by the causal role of mental states and events (e.g., desires and beliefs) involving the agent. Franklin boldly counteracts a dominant theory (...) that has similar aims, put forth by well-known philosopher Robert Kane. -/- Many philosophers contend that event-causal libertarians have no advantage over compatibilists when it comes to securing a distinctively valuable kind of freedom and responsibility. To Franklin, this position is mistaken. Assuming agency reductionism is true, event-causal libertarians need only adopt the most plausible compatibilist theory and add indeterminism at the proper juncture in the genesis of human action. The result is minimal event-causal libertarianism: a model of free will with the metaphysical simplicity of compatibilism and the intuitive power of libertarianism. And yet a worry remains: toward the end of the book, Franklin reconsiders his assumption of agency reductionism, arguing that this picture faces a hitherto unsolved problem. This problem, however, has nothing to do with indeterminism or determinism, or even libertarianism or compatibilism, but with how to understand the nature of the self and its role in the genesis of action. Crucially, if this problem proves unsolvable, then not only is event-causal libertarianism untenable, so also is event-causal compatibilism. (shrink)

This groundbreaking handbook of character strengths and virtues is the first progress report from a prestigious group of researchers who have undertaken the systematic classification and measurement of widely valued positive traits. Character Strengths and Virtues classifies twenty-four specific strengths under six broad virtues that consistently emerge across history and culture. This book demands the attention of anyone interested in psychology and what it can teach about the good life.

This article outlines in details specific experiments that Galen performed. It explores how his methodology for experimentation was a sophisticated response to the rationalist-empirist debate as it occurred in ancient medicine. -/- .

Advertising and other forms of promotional activity have proliferated to such an extent that they may constitute a form of social pollution (Kitchen, 1994). The quantity and tone of communications to which consumers are exposed may have a subtle but pervasive effect on the social ecology of the developed world. Not only are Marketing Communications delivered in unprecedented quantities (Kitchen, 1994); but their tone is increasingly difficult to categorise in the Postmodern Marketing era (Brown, 1994). Notably, there has been very (...) little research conducted on this seeming "Leviathan" (Kitchen, 1994, after Hobbes, 1651) effect. Ethical concerns of professional marketing bodies such as the MRS and CIM are focussed on the conduct of professionals with regard to law and notions of moral decency in human exchange relationships (see MRS code of conduct, ASA and IBA guidelines). There is less emphasis on the ethical implications for society of the totality of Marketing Communication activities. This paper examines the distinctively Postmodern concept of the Communications Leviathan and discusses contemporary ethical issues, drawing perspectives where possible from Postmodern critical theory, Enlightenment philosophy, cognitive psychology and classical ethical works of Plato and Aristotle. (shrink)

Four Phenomenological Philosophers is the first book to examine the major texts of the leading figures of phenomenology in one volume. In separate chapters, the book explores the ideas of Edmund Husserl, Martin Heidegger, Jean-Paul Sartre and Maurice Merleau-Ponty with detailed readings of their most important texts. The constantly evolving ideas of Edmund Husserl, the founder of phenomenology, are presented through a review of the three major periods of his work. Martin Heidegger, who made a decisive and controversial break with (...) his teacher, Husserl, set forth his own phenomenological program in Being and Time. Jean-Paul Sartre, who transplanted the tradition from its origins in Germany to the streets of Paris, set forth his existential phenomenology in Being and Nothingness. The Phenomenology of Perception was the best and most representative work of Maurice Merleau-Ponty, a contemporary of Sartre whose career was cut short by his early death. A knowledge of these key thinkers and their major texts is essential to an understanding of many of the major themes of contemporary philosophy, from hermeneutics and existentialism to postmodernism and deconstructivism. This book provides the ideal introduction to this important philosophical tradition. (shrink)

ABSTRACT:This article examines the place of Machiavelli’sPrincein the history of ethics and the history of leadership philosophy. Close scrutiny indicates that Machiavelli advances an ethical system for leadership that involves uprooting corruption and establishing rule of law. He draws on history and current affairs in order to obtain a realistic understanding of human behavior that forms a basis for a consequentialist ethics. While he claims a good leader might do bad things, this is in situations where necessity constrains a prince (...) to choosing the “least bad” course of action. Furthermore, Machiavelli advocates winning the goodwill of followers through leadership as a source of power. Machiavelli’s leadership ethics has a sophistication not fully enjoyed by his reputation in management scholarship. He would not score as especially “Machiavellian” on the Mach IV. Many of his ideas contain seeds for theories that are now considered important for leadership today. (shrink)

Martin Heidegger (1899-1976), born in Baden, Germany, is one of the most important philosophers of the twentieth century. The one-time assistant of Edmund Husserl, the founder of the phenomenological movement, Heidegger established himself as an independent and original thinker with the publication of his major work Being and Time in 1927. This collection of papers is the most comprehensive and international examination of Heidegger's work available. It contains established classic articles, some appearing in English for the first time, and many (...) original pieces provided especially for this collection. The cross-cultural and political aspects of Heidegger's thought are examined, including his relationship to the Nazi party. The purpose of this collection is to provide a critical examination of Heidegger's work which evaluates its limits as well as its strengths, and to assess the prospects for the future development of his thought. Since many of the leading themes of contemporary philosophy such as hermeneutics, phenomenology, existentialism, postmodernism and deconstructivism trace their intellectual heritage back to Heidegger, this collection will be an indispensable guide to the issues which are currently being disputed in the field of philosophy. (shrink)

This paper explores the anatomical foundations of Aristotle's natural philosophy. Rather than simply looking at the body, he contrives specific procedures for revealing unmanifest phenomena. In some cases, these interventions seem extensive enough to qualify as experiments. At the work bench, one can observe the parts of animals in the manner Aristotle describes, even if his descriptions seem at odds with 20th century textbooks. Manipulating animals allows us to recover his teleological thought more fully. This consideration of Aristotle as a (...) sophisticated biologist helps our reading of his writings in other areas of philosophy. (shrink)

Paxillin is a recently identified member of the complex of cytoskeletal proteins that is found concentrated in cultured cells and in vivo at the cytoplasmic face of regions of cell attachment to the extracellular matrix. These sites, in view of their close proximity to the extracellular matrix, are well positioned to act as signal‐transducing centers to ‘report on’ changes in the cells, immediate environment. Recent findings indicate that such signals are in part mediated through the activation of tyrosine kinases concentrated (...) at the sites of adhesion. Changes in the phosphotyrosine content of paxillin accompanying this elevation in kinase activity suggest that paxillin may be an important intermediary in these pathways. (shrink)

This Companion offers a state-of-the-art survey of the work of John Stuart Mill – one which covers the historical influences on Mill, his theoretical, moral and social philosophy, as well as his relation to contemporary movements. Its contributors include both senior scholars with established expertise in Mill’s thought and new emerging interpreters. Each essay acts as a ‘go-to’ resource for those seeking to understand an aspect of Mill’s thought or to familiarise themselves with the contours of a debate within the (...) scholarship. The Companion is a key reference on Mill’s theory of liberty and utilitarianism, but also provides a valuable resource on lesser-known aspects of his work, including his epistemology, metaphysics, and philosophy of language. The volume is divided into six sections. Part I covers Mill’s life, his immediate posthumous reputation, and his own telling of his life-story. Part II brings together an accessible and comprehensive summary of the various influences on Mill’s thought. Part III offers an account of the foundations of Mill’s philosophy and his thought on key philosophic topics. Parts IV and V tackle issues from Mill’s moral and social philosophy. Part VI concludes with a treatment of the broader aspects of Mill’s thought, tracing his relation to major movements in philosophy. (shrink)

_Critical Heidegger_ brings together a selection of the best work on Martin Heidegger from a number of key commentators working in Europe. These new and classic essays, for the most part translated from German and French originals, are an essential guide to the current European reception of Heidegger and make available essays that have had considerable impact on English-language Heidegger studies. Essays in this collection: * Marlene Zarader, `The mirror with the triple reflection' * Franco Volpi, `Dasein and Praxis: Aristotle' (...) * Jean-Luc Marion, `Heidegger on Descartes' * Christopher Macann, `Heidegger's Kant Interpretation' * Michel Haar, `Critical Remarks on the Heideggerian Reading of Nietzsche' * Maria Villela-Petit, `Heidegger's Conception of Space' * Francoise Dastur, `The ekstatico-horizontal constitution of temporality' * F-W von Herrmann, `Way and Method in Philosophy' * Samuel Ijsseling, `The End of Philosophy as the Commencement of Thinking' * Otto Poggler, `Does the saving power also grow? Heidegger's last paths' * Ernst Tugendhat, `Heidegger's Idea of Truth' * Karl-Otto Apel, `Wittgenstein and Heidegger'. (shrink)

A tendency of auditory cortical neurons to respond at the beginning of major transitions in sounds rather than providing a continuously updated spectral-temporal profile may impede the generation of combination-sensitivity for certain classes of stimuli. Potential consequences of the cortical encoding of voiced stop-consonants on representational principles derived from orderly output constraints are discussed.

Many of the most virulent and problematic eukaryotic pathogens have evolved from photosynthetic ancestors, such as apicomplexans, which are responsible for a wide range of diseases including malaria and toxoplasmosis. The primary barrier to understanding the early stages of evolution of these parasites has been the difficulty in finding parasites with closely related free‐living lineages with which to make comparisons. Parasites found throughout the florideophyte red algal lineage, however, provide a unique and powerful model to investigate the genetic origins of (...) a parasitic lifestyle. This is because they share a recent common ancestor with an extant free‐living red algal species and parasitism has independently arisen over 100 times within this group. Here, we synthesize the relevant hypotheses with respect to how these parasites have proliferated. We also place red algal research in the context of recent developments in understanding the genome evolution of other eukaryotic photosynthesizers turned parasites. (shrink)

Although in fundamental agreement with Carpendale & Lewis 's position, we discuss a potential source of confusion regarding the socially constituted nature of mental states. Drawing from recent work by Kusch, we argue, more specifically, that mental states are instances of “artificial kinds,” and so, stand between the more common classificatory extremes of “the natural” and “the social.”.

Deciphering how DCAFs (DDB1‐CUL4 Associated Factors) modulate a broad spectrum of cellular processes, including cell cycle progression and maintenance of genomic integrity is critical to better understand cellular homeostasis and diseases. Cells contain more than 100 DCAFs that associate with the Cullin‐Ring Ubiquitin Ligase 4 (CRL4) complex that target specific protein substrates for degradation. DCAFs are thought to act as substrate receptors that dictate the specificity of the ubiquitination machinery (“catalytic DCAFs”). However, recent studies have suggested that some DCAFs might (...) play a different role by targeting CRL4 complexes to distinct cellular compartments (“structural DCAFs”). Once localized to their correct cellular domains, these CRLs dissociate from the structural DCAFs prior to their association with other, substrate‐specific catalytic DCAFs. Thus, we propose that DCAF switches can provide a mechanistic basis for the degradation of proteins that regulate cell growth and proliferation at precise points in space and time. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

Contributions to this volume examine three main areas relating to the metaphysics of Thomas Aquinas: the foundation of metaphysics within Thomism; the use of metaphysics in fundamental philosophical issues within Thomism; and the use of metaphysics in central theological issues.

In this paper I seek to defend libertarianism about free will and moral responsibility against two well-known arguments: the luck argument and the Mind argument. Both of these arguments purport to show that indeterminism is incompatible with the degree of control necessary for free will and moral responsibility. I begin the discussion by elaborating these arguments, clarifying important features of my preferred version of libertarianism—features that will be central to an adequate response to the arguments—and showing why a strategy of (...) reconciliation (often referred to as “deliberative libertarianism”) will not work. I then consider four formulations of the luck argument and find them all wanting. This discussion will place us in a favorable position to understand why the Mind argument also fails. (shrink)

A familiar feature of our moral responsibility practices are pleas: considerations, such as “That was an accident”, or “I didn’t know what else to do”, that attempt to get agents accused of wrongdoing off the hook. But why do these pleas have the normative force they do in fact have? Why does physical constraint excuse one from responsibility, while forgetfulness or laziness does not? I begin by laying out R. Jay Wallace’s (Responsibility and the moral sentiments, 1994 ) theory of (...) the normative force of excuses and exemptions. For each category of plea, Wallace offers a single governing moral principle that explains their normative force. The principle he identifies as governing excuses is the Principle of No Blameworthiness without Fault: an agent is blameworthy only if he has done something wrong. The principle he identifies as governing exemptions is the Principle of Reasonableness: an agent is morally accountable only if he is normatively competent. I argue that Wallace’s theory of exemptions is sound, but that his account of the normative force of excuses is problematic, in that it fails to explain the full range of excuses we offer in our practices, especially the excuses of addiction and extreme stress. I then develop a novel account of the normative force of excuses, which employs what I call the “Principle of Reasonable Opportunity,” that can explain the full range of excuses we offer and that is deeply unified with Wallace’s theory of the normative force of exemptions. An important implication of the theory I develop is that moral responsibility requires free will. (shrink)

Seemingly one of the most prominent issues that divide theorists about free will and moral responsibility concerns whether the ability to do otherwise is necessary for freedom and responsibility. I defend two claims in this paper. First, that this appearance is illusory: everyone thinks an ability to do otherwise is necessary for freedom and responsibility. The central issue is not whether the ability to do otherwise is necessary for freedom and responsibility but which abilities to do otherwise are necessary. Second, (...) I argue that we cannot determine which abilities are necessary until we have determined the nature and justification of moral responsibility. Thus, theorizing about moral responsibility ought to take pride of place in theorizing about free will. (shrink)

Event-causal libertarians maintain that an agent’s freely bringing about a choice is reducible to states and events involving him bringing about the choice. Agent-causal libertarians demur, arguing that free will requires that the agent be irreducibly causally involved. Derk Pereboom and Meghan Griffith have defended agent-causal libertarianism on this score, arguing that since on event-causal libertarianism an agent’s contribution to his choice is exhausted by the causal role of states and events involving him, and since these states and events leave (...) it open which decision he will make, he does not settle which decision occurs, and thus “disappears.” My aim is to explain why this argument fails. In particular, I demonstrate that event-causal libertarians can dismantle the argument by enriching the reductive base in their analysis of free will to include a state that plays the functional role of the self-determining agent and with which the agent is identified. (shrink)

“Free Will” is a philosophical term of art for a particular sort of capacity of rational agents to choose a course of action from among various alternatives. Which sort is the free will sort is what all the fuss is about. (And what a fuss it has been: philosophers have debated this question for over two millenia, and just about every major philosopher has had something to say about it.) Most philosophers suppose that the concept of free will is very (...) closely connected to the concept of moral responsibility. Acting with free will, on such views, is just to satisfy the metaphysical requirement on being responsible for one's action. (Clearly, there will also be epistemic conditions on responsibility as well, such as being aware—or failing that, being culpably unaware—of relevant alternatives to one's action and of the alternatives' moral significance.) But the significance of free will is not exhausted by its connection to moral responsibility. Free will also appears to be a condition on desert for one's accomplishments (why sustained effort and creative work are praiseworthy); on the autonomy and dignity of persons; and on the value we accord to love and friendship. (See Kane 1996, 81ff. and Clarke 2003, Ch.1.). (shrink)

Liver transplantation is the treatment of choice for many forms of liver disease. Unfortunately, the scarcity of cadaveric donor livers limits the availability of this technique. To improve the availability of liver transplantation, surgeons have developed the capability of removing a portion of liver from a live donor and transplanting it into a recipient. A few liver transplants using living donors have been performed worldwide.Our purpose was to analyze the ethics of liver transplants using living donors and to propose guidelines (...) for the procedure before it was introduced in the United States. We used a process of research ethics consultation that involves a collaboration between clinical investigators and clinical ethicists. We concluded that it was ethically appropriate to perform liver transplantation using living donors in a small series of patients on a trial basis, and we published our ethical guidelines in a medical journal before the procedure was introduced. We recommend this prospective, public approach for the introduction of other innovative therapies in medicine and surgery. (shrink)

A crucial question for libertarians about free will and moral responsibility concerns how their accounts secure more control than compatibilism. This problem is particularly exasperating for event-causal libertarianism, as it seems that the only difference between these accounts and compatibilism is that the former require indeterminism. But how can indeterminism, a mere negative condition, enhance control? This worry has led many to conclude that the only viable form of libertarianism is agent-causal libertarianism. In this paper I show that this conclusion (...) is premature. I explain how event-causal libertarianism secures more control than compatibilism by offering a novel argument for incompatibilism. Part of the reason my solution has gone unnoticed is that it is often mistakenly assumed that an agent's control is wholly exhausted by the agent's powers and abilities. I argue, however, that control is constituted not just by what we have the ability to do, but also by what we have the opportunity to do. And it is by furnishing agents with new opportunities that event-causal libertarianism secures enhanced control. In order to defend this claim, I provide an analysis of opportunities and construct a novel incompatibilist argument to show that the opportunity to do otherwise is incompatible with determinism. (shrink)